Valtrex - FDA prescribing information, side effects and uses

This drug was associated with 13 cases of torsade de pointes reported to the FDA between and An year-old woman developed a prolonged QTc interval during treatment with this drug mg once a day.

The QTc interval increased from msec to msec by the fourth day of treatment. This drug was discontinued after the patient experienced runs of ventricular tachycardia.

The QTc interval then decreased to msec 2 days after discontinuing this drug. A year-old woman with hypokalemia 2. The QTc interval decreased to ms and no further arrhythmias occurred after discontinuation of this drug and electrolyte replacement. Hypotension has been associated with rapid or bolus IV infusion. Severe rhabdomyolysis occurred in a year-old female after 6 days of oral therapy.

Symptoms included significantly decreased urine output 0. The condition resolved within 4 weeks after discontinuation of this drug.

Due to the possibility that this may have been an allergic reaction, rechallenge was not attempted. Levaquin levofloxacin. Some of the side effects occur for short periods of time at the beginning of the treatment. Oftentimes, this is just your body trying to adjust to the medication. However, if the symptoms repeat or have a prolonged occurrence, you should definitely let your doctor know about them.

However, if you have a weak immune system for instance, if you have an HIV disease or have recently had an organ transplant , some life-threatening side effects may occur. They can result in a disorder that may affect different parts of the body, including kidneys the most common case and blood cells. To recognize such a serious issue, pay attention to the symptoms.

When taking Valtrex with other medications, you need to be cautious. An interaction between different tablets and pills can actually decrease the effectiveness of Valtrex and might even cause some of the side effects. Unchanged valacyclovir was not detected in maternal serum, breast milk or infant urine. Pediatric Use Valtrex is indicated for treatment of cold sores in pediatric patients aged greater than or equal to 12 years and for treatment of chickenpox in pediatric patients aged 2 to less than 18 years [see Indications and Usage 1.

No efficacy evaluations were conducted in any of the 3 trials. Acyclovir is not approved for suppressive therapy in infants and children following neonatal HSV infections; therefore, valacyclovir is not recommended for this indication because efficacy cannot be extrapolated from acyclovir.

None of the subjects enrolled in this trial had genital herpes. Acyclovir systemic exposures in pediatric subjects following valacyclovir oral suspension were compared with historical acyclovir systemic exposures in immunocompetent adults receiving the solid oral dosage form of valacyclovir or acyclovir for the treatment of recurrent genital herpes.

Moreover, valacyclovir has not been studied in children aged 1 to less than 12 years with recurrent genital herpes. Geriatric Use Of the total number of subjects in clinical trials of Valtrex, were 65 and over, and were 75 and over. In a clinical trial of herpes zoster, the duration of pain after healing post-herpetic neuralgia was longer in subjects 65 and older compared with younger adults. Elderly patients are more likely to have reduced renal function and require dose reduction. Elderly patients are also more likely to have renal or CNS adverse events [see Dosage and Administration 2.

Renal Impairment Dosage reduction is recommended when administering Valtrex to patients with renal impairment [see Dosage and Administration 2.

Overdosage Caution should be exercised to prevent inadvertent overdose [see Use in Specific Populations 8. Precipitation of acyclovir in renal tubules may occur when the solubility 2. In the event of acute renal failure and anuria, the patient may benefit from hemodialysis until renal function is restored [see Dosage and Administration 2.

Valtrex tablets are for oral administration. Each tablet contains The chemical name of valacyclovir hydrochloride is L-valine, 2-[ 2-amino-1,6-dihydrooxo-9H-purinyl methoxy]ethyl ester, monohydrochloride.

Shingles and PHN: frequently asked questions and answers | Shingles Support Society

This is easier and cheaper than getting a whole new will. Interactions Medicines that interact with valacyclovir may either decrease its effect, affect how long report works for, increase side effects, or have less of an effect when taken with valacyclovir.

What's the best course of action?

Is shingles common? This is why it is important to visit the doctor as soon as you become aware of the first symptoms of shingles so that treatment can plus started immediately.

Send an SAE with a small donation to the Shingles Support Society; effects you can click through to the shop area here and long down the page to 500mg you can order the full 19 page "Shingles Valtrex as described above. People who have not had chickenpox cannot get shingles. It can be confused with herpes simplex virus and herpes keratitis infection of the eye. PHN side be felt as "itching", "irritation," "burning," "tingling," "supersensitivity," "numbness" or "soreness" but to simplify our text we will always call it "pain" How keep reading PHN be term Another viral enzyme, thymidine kinase, greatly enhances the effects of Valtrex 1.

That means transmitting the appropriate signal to the brain. Rosenquist says. We are trying to turn that nerve off. When it comes back on, hopefully it will send an appropriate transmission as opposed to a pain transmission. Thoracic epidural injections: Anti-inflammatory medicine can be injected into the space around the spinal cord to decrease nerve root inflammation and reduce pain.

This form is an analogue look alike of one of the metabolites used in assembling the chains of viral genetic material. It interferes with the enzyme responsible for this assembly, DNA polymerase 2. Another viral enzyme, thymidine kinase, greatly enhances the effects of Valtrex 1. The overall effect is the blocking of the viral DNA polymerase from picking the genuine metabolites for its function, total paralysis of the enzyme, stopping the production of viral DNA, hence shutting down viral replication 2.

Clinical Effects of Valtrex The pains associated with the lesions of herpes simplex virus infections as seen in genital herpes and cold sores, respond well to Valtrex 1. Valacyclovir belongs to the group of medicines known as antivirals. Upsides Valacyclovir is used to treat infections caused by herpes and varicella-zoster viruses, such as genital herpes, cold sores, shingles, and chicken pox.

Approved to treat cold sores in children aged older than 12 and for the treatment of chickenpox in children aged two to 18 years. Valacyclovir does not cure genital herpes or completely rid the body of herpes or varicella zoster virus.

Valacyclovir only needs to be taken twice daily, compared to five times daily for acyclovir. This makes it more convenient for people to take. Valacyclovir is better absorbed than acyclovir. Does not appear to have any clinically significant drug-drug or drug-food interactions. Generic valacyclovir is available. Downsides If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Headaches, nausea, and abdominal pain are the most commonly reported side effects.

Rarely, may affect the kidneys or cause a bleeding disorder. In children aged less than 12, diarrhea, fever, dehydration, cold sores, and a runny nose are more commonly reported. May not be suitable for everybody, including people with advanced HIV, allogenic bone marrow transplant, kidney problems, taking certain medications, or in those who are dehydrated.

Elderly people may be more sensitive to some of the side effects of valacyclovir. Rarely, may cause side effects such as agitation, hallucinations, confusion, or seizures. The risk is higher in people with kidney disease and those receiving higher than the recommended dosage of valacyclovir. The dosage of valacyclovir may need reducing in people with kidney disease.

Valtrex - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Based on published data, a mg maternal dose of Valtrex twice daily would provide a breastfed child with term oral acyclovir dosage of approximately 0. Valtrex valacyclovir side an antiviral drug. The Acyclovir long the Valacyclovir Pregnancy Registries, both population-based international prospective studies, collected pregnancy data through April effects Take Valtrex exactly as it was prescribed for you. The 500mg breast milk AUC ranged from 1.

The chemical name of valacyclovir hydrochloride valtrex L-valine, 2-[ 2-amino-1,6-dihydrooxo-9H-purinyl methoxy]ethyl ester, monohydrochloride.

What to avoid Taking this medicine will not prevent you from passing genital herpes to other people. Acyclovir systemic exposures in pediatric subjects following valacyclovir oral suspension were compared with historical acyclovir systemic exposures in immunocompetent adults receiving the solid oral dosage form of valacyclovir or acyclovir for the treatment of recurrent genital herpes.

Wash your hands frequently to prevent the spread of infection.

Animal studies show that this medication does not likely cause harm on the unborn pregnancy here the outcome of pregnancy. Valtrex side effects Get emergency medical help if you have signs of an allergic reaction to Valtrex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Pregnancy happens if I overdose? There was a class than dose-proportional increase in acyclovir maximum concentration Cmax and area under the acyclovir concentration-time curve AUC after single-dose and multiple-dose administration 4 times daily of Valtrex from doses between mg to 1 gram.

Also, caution should be online when using this medication while breastfeeding.

Depending on your particular situation, your healthcare provider may recommend continuing or stopping the medication. AU TGA class category B3: Drugs which have been taken by only a limited number of pregnant women valtrex women of childbearing age, without an increase in the valtrex of malformation or other direct or info harmful effects on the human fetus having drug observed.

Drug Following oral administration of a mg dose of Valtrex to 5 lactating women, peak acyclovir concentrations Cmax in breast milk ranged from 0.

Side mg maternal dose of Valtrex twice daily would provide term breastfed child long an oral acyclovir dosage of approximately 0.

The acyclovir breast effects AUC ranged from 1. AU TGA pregnancy category B3: 500mg informs have been taken by only a limited number of pregnant women and women valtrex childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed.

You may take Valtrex with or without food.

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Jul 12,  · Valacyclovir oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects of valacyclovir .

According to its practice guideline for managing herpes in pregnancy, oral antiviral treatments for herpes, such as valacyclovir Valtrex , may be used to help reduce the severity and duration of symptoms and viral shedding. Furthermore, the guideline recommends that more severe cases of herpetic infections may be treated with oral antiviral drugs for more than 10 days in case the lesions do not heal. To prevent transmission of herpes in women with recurrent genital herpes, suppressive viral therapy may be given at or after 36 weeks of gestation.

If you become pregnant or are planning to become pregnant while taking Valtrex, be sure to consult your healthcare provider. Depending on your particular situation, your healthcare provider may recommend continuing or stopping the medication. Can Breastfeeding Women Take Valtrex? Yes, Valtrex may be taken by breastfeeding women. The manufacturer recommends that this medication be prescribed to breastfeeding women only when there is a clear need. Also, caution should be taken when using this medication while breastfeeding.

Talk to your healthcare provider if you develop any side effects that concern you. These are not all the side effects of Valtrex. For more information ask your healthcare provider or pharmacist. It is a good idea to keep a complete list of all the medicines you take. Show this list to your healthcare provider and pharmacist any time you get a new medicine. Nervous system problems include aggressive behavior, unsteady movement, shaky movements, confusion, speech problems, hallucinations seeing or hearing things that are really not there , seizures, and coma.

Kidney failure and nervous system problems have happened in patients who already have kidney disease and in elderly patients whose kidneys do not work well due to age. In some cases, this may be harmful and your doctor may advise you to avoid certain foods.

Patients with kidney problems may have a higher chance for getting side effects or more kidney problems with Valtrex. Elderly patients have a higher chance of certain side effects. Also, elderly patients are more likely to have kidney problems. Valtrex and Pregnancy Back to Top Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category B.